My research focuses on adipose tissue formation and function, especially in the context of endocrinology and metabolism. During my PhD (Institute of Metabolic Science, University of Cambridge) I studied the regulation of adipogenesis by tumour necrosis factor-alpha. My postdoctoral research with Professor Ormond MacDougald (University of Michigan) initially focused on mesenchymal stem cell fate, but I soon I began studying bone marrow adipose tissue (BMAT). Unlike other adipose subtypes, BMAT has been largely ignored by modern biomedical research. This research identified BMAT as an endocrine organ that may contribute to systemic adaptations to caloric restriction. In 2015 I moved to the University of Edinburgh to further study BMAT as a principal investigator.
With funding from the Medical Research Council, The British Heart Foundation and the Wellcome Trust, my lab continues to investigate the endocrine functions of BMAT through studies that include novel mouse models, imaging approaches and clinical sample analysis.